Millet allergy is relatively uncommon compared to major allergens (wheat, milk, eggs, peanuts). However, clinical literature documents both immediate-type (IgE-mediated) and delayed-type hypersensitivity reactions to millet proteins. A review of food allergy literature indexed in PubMed notes that millet allergies, while rare, can present as serious reactions in sensitized individuals.

Key facts about millet allergy:

Prevalence: Millet allergy is uncommon globally; it is more prevalent in populations with high traditional millet consumption.

Anaphylaxis: The most serious documented reaction is anaphylaxis following millet ingestion in sensitized individuals — characterized by urticaria, angioedema, bronchospasm, and hypotension.

Occupational asthma: Inhalation of millet flour in bakers, animal feed handlers, and grain processors has been associated with occupational asthmatic attacks and allergic rhinitis.

Cross-reactivity: Millet proteins may cross-react with grass pollen allergens; individuals with grass pollen allergies may have higher risk of millet sensitization (pollen-food allergy syndrome).

Diagnosis: Skin prick tests and specific IgE blood tests (ImmunoCAP) can diagnose millet allergy; oral food challenges under medical supervision confirm clinical reactivity.

Management: Confirmed millet-allergic individuals should avoid all forms of millet and carry an epinephrine auto-injector (EpiPen) as per allergist guidance.

Note for parents: Infant sensitization risk is low but warrants monitoring when introducing millets as complementary foods; introduce one grain at a time.